{"id":10160,"date":"2025-12-24T15:09:02","date_gmt":"2025-12-24T13:09:02","guid":{"rendered":"https:\/\/suprastratum.com\/?p=10160"},"modified":"2026-04-20T15:28:22","modified_gmt":"2026-04-20T12:28:22","slug":"creatine-womens-health","status":"publish","type":"post","link":"https:\/\/suprastratum.com\/en\/2025\/12\/24\/creatine-womens-health\/","title":{"rendered":"CREATINE AND WOMEN'S HEALTH"},"content":{"rendered":"<p style=\"text-align: justify;\">This article examines the effects of creatine on women's health.<br \/>\n<!--more--><br \/>\nCreatine supplementation in women has attracted attention for its potential benefits beyond muscle growth, including reproductive health, cognitive health, and aging. As women have distinct physiological differences from men, influenced by hormonal fluctuations during perimenopause, pregnancy, and menopause, these factors must be taken into account for their effect on creatine metabolism.<\/p>\n<p style=\"text-align: justify;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"10097\" data-permalink=\"https:\/\/suprastratum.com\/en\/2025\/11\/20\/lifestyle-changes-hypertension-management\/dakos-3538425_640\/\" data-orig-file=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/11\/dakos-3538425_640.jpg?fit=640%2C427&amp;ssl=1\" data-orig-size=\"640,427\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"dakos-3538425_640\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/11\/dakos-3538425_640.jpg?fit=640%2C427&amp;ssl=1\" class=\"aligncenter size-full wp-image-10097\" src=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/creatine1-z0nVqfrOqWA-unsplash.jpg?resize=320%2C214&#038;ssl=1\" alt=\"Creatine, nutrition, dietary supplements\" width=\"320\" height=\"214\" \/><\/p>\n<h1 style=\"text-align: center;\"><span style=\"text-decoration: underline;\"><strong>CREATINE IN PREMENOPAUSE<\/strong><\/span><\/h1>\n<p style=\"text-align: justify;\">The menstrual cycle consists of two distinct phases: the follicular phase and the luteal phase. These phases are characterized by fluctuations mainly in estrogen and progesterone, which cause many of the physiological changes that occur during the cycle and can also affect creatine metabolism.<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/doi.org\/10.1002\/fsn3.4135\" target=\"_blank\" rel=\"noopener\">Recent studies show that dietary creatine intake in women is suboptimal<\/a>, which is associated with a higher risk of oligomenorrhea, pelvic infection, hysterectomy, and oophorectomy.<\/p>\n<p style=\"text-align: justify;\">The molecular structure of creatine allows water molecules to bind and transport this water from the extracellular fluid to the intracellular space.<\/p>\n<p style=\"text-align: justify;\">Cyclical changes during the menstrual cycle, particularly in the luteal phase, cause changes in fluids with greater extracellular fluid retention, often leading women to report feelings of bloating.<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/doi.org\/10.3390\/nu15020429\" target=\"_blank\" rel=\"noopener\">Studies have shown<\/a> that creatine supplementation can improve total body water by transporting extracellular fluid into the cell, particularly during the luteal phase, regardless of hormonal contraceptive use and without changes in body weight, suggesting that creatine monohydrate as a dietary supplement may be beneficial for promoting cellular hydration.<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/doi.org\/10.1080\/15502783.2025.2533651\" target=\"_blank\" rel=\"noopener\">In a recent study<\/a>, creatine intake (20 g\/day for 5 days) led to improvements in phase angle, an indicator of cell mass and health, during the follicular phase and luteal phase.<\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"10191\" data-permalink=\"https:\/\/suprastratum.com\/en\/2025\/12\/24\/creatine-womens-health\/kelly-sikkema-ixynwpnrsgu-unsplash\/\" data-orig-file=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?fit=640%2C398&amp;ssl=1\" data-orig-size=\"640,398\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"kelly-sikkema-ixYNwpnRsGU-unsplash\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;sssssss&lt;\/p&gt;\" data-large-file=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?fit=640%2C398&amp;ssl=1\" class=\"aligncenter size-full wp-image-10191\" src=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?resize=320%2C199&#038;ssl=1\" alt=\"Creatine, nutrition, dietary supplements\" width=\"320\" height=\"199\" srcset=\"https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?w=640&amp;ssl=1 640w, https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?resize=300%2C187&amp;ssl=1 300w, https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?resize=18%2C12&amp;ssl=1 18w, https:\/\/i0.wp.com\/suprastratum.com\/wp-content\/uploads\/2025\/12\/kelly-sikkema-ixYNwpnRsGU-unsplash.jpg?resize=563%2C350&amp;ssl=1 563w\" sizes=\"auto, (max-width: 320px) 85vw, 320px\" \/><\/p>\n<h1 style=\"text-align: center;\"><span style=\"text-decoration: underline;\"><strong>CREATINE AND SLEEP IMPROVEMENT<\/strong><\/span><\/h1>\n<p style=\"text-align: justify;\">Sleep disorders are a significant factor in the mental health challenges faced by young women. Many studies show <a href=\"https:\/\/doi.org\/10.1007\/s40279-023-01870-9\" target=\"_blank\" rel=\"noopener\">that creatine supplementation<\/a> <a href=\"https:\/\/doi.org\/10.3390\/nu13020586\" target=\"_blank\" rel=\"noopener\">may have beneficial effects<\/a> <a href=\"https:\/\/doi.org\/10.1016\/j.exger.2018.04.013\" target=\"_blank\" rel=\"noopener\">in indicators of brain health and function<\/a>, with a possible effect on sleep, as it may influence cognitive processes related to sleep deprivation, which potentially has significant implications for the quality, continuity, and quantity of sleep.<\/p>\n<p style=\"text-align: justify;\">By supporting sleep regulation, creatine supplementation may offer a new approach to improving the mental health of young women.<\/p>\n<h1 style=\"text-align: center;\"><span style=\"text-decoration: underline;\"><strong>CREATINE AND PREGNANCY<\/strong><\/span><\/h1>\n<p style=\"text-align: justify;\">There is growing evidence of changes in creatine homeostasis during healthy human pregnancy, as well as during pregnancy complications associated with hypoxia or restricted nutrient supply to the developing fetus.<\/p>\n<p style=\"text-align: justify;\">A recent analysis found that approximately <a href=\"https:\/\/doi.org\/10.1159\/000520818\" target=\"_blank\" rel=\"noopener\">6 out of 10 pregnant women in the US consume creatine below the recommended amounts<\/a> for an adult woman, while another data evaluation found that women with <a href=\"https:\/\/doi.org\/10.1002\/fsn3.4135\" target=\"_blank\" rel=\"noopener\">suboptimal creatine intake had a higher risk of obstetric problems<\/a>.<\/p>\n<p style=\"text-align: justify;\">Finally, adequate creatine intake (7-8 mg\/kg\/day)<a href=\"https:\/\/doi.org\/10.1093\/cdn\/nzac061.083\" target=\"_blank\" rel=\"noopener\"> during the first 1,000 days of life may also be critical for children's long-term well-being<\/a>, as analyses appear to show a relationship between dietary creatine consumption and head circumference in children aged 0-2 years.<\/p>\n<p style=\"text-align: justify;\">-Suprastratum: The authority on health, fitness and nutrition<\/p>\n<p>Sources\/bibliography\/more reading:<\/p>\n<ul>\n<li><em><a href=\"https:\/\/doi.org\/10.1007\/s00726-016-2199-y\" target=\"_blank\" rel=\"noopener noreferrer\">Ellery SJ, Walker DW, Dickinson H. Creatine for women: a review of the relationship between creatine and the reproductive cycle and female-specific benefits of creatine therapy. Amino Acids. 2016 Aug;48(8):1807-17. doi: 10.1007\/s00726-016-2199-y. Epub 2016 Feb 22. PMID: 26898548.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1002\/fsn3.4135\" target=\"_blank\" rel=\"noopener noreferrer\">Ostojic SM, Stea TH, Ellery SJ, Smith-Ryan AE. Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017-2020. Food Sci Nutr. 2024 Apr 30;12(7):4893-4898. doi: 10.1002\/fsn3.4135. PMID: 39055234; PMCID: PMC11266896.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.3390\/nu15020429\" target=\"_blank\" rel=\"noopener noreferrer\">Moore SR, Gordon AN, Cabre HE, Hackney AC, Smith-Ryan AE. A Randomized Controlled Trial of Changes in Fluid Distribution across Menstrual Phases with Creatine Supplementation. Nutrients. 2023 Jan 13;15(2):429. doi: 10.3390\/nu15020429. PMID: 36678300; PMCID: PMC9865497.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1080\/15502783.2025.2533651\" target=\"_blank\" rel=\"noopener noreferrer\">Moore SR, Gordon AN, Mutuwa AG, Hackney AC, Brown A, Smith-Ryan AE. The effects of creatine loading on cellular integrity and jump performance across the menstrual cycle. J Int Soc Sports Nutr. 2025:2533651. doi: 10.1080\/15502783.2025.2533651. Epub 2025 Aug 20.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1007\/s40279-023-01870-9\" target=\"_blank\" rel=\"noopener noreferrer\">Candow DG, Forbes SC, Ostojic SM, Prokopidis K, Stock MS, Harmon KK, Faulkner P. \u201cHeads Up\u201d for Creatine Supplementation and its Potential Applications for Brain Health and Function. Sports Med. 2023 Dec;53(Suppl 1):49-65. doi: 10.1007\/s40279-023-01870-9. Epub 2023 Jun 27. Erratum in: Sports Med. 2024 Jan;54(1):235-236. doi: 10.1007\/s40279-023-01888-z. PMID: 37368234; PMCID: PMC10721691.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.3390\/nu13020586\" target=\"_blank\" rel=\"noopener noreferrer\">Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine Supplementation and Brain Health. Nutrients. 2021 Feb 10;13(2):586. doi: 10.3390\/nu13020586. PMID: 33578876; PMCID: PMC7916590.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1016\/j.exger.2018.04.013\" target=\"_blank\" rel=\"noopener noreferrer\">Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018 Jul 15;108:166-173. doi: 10.1016\/j.exger.2018.04.013. Epub 2018 Apr 25. PMID: 29704637; PMCID: PMC6093191.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1093\/cdn\/nzac061.083\" target=\"_blank\" rel=\"noopener noreferrer\">Ostojic, S., Korovljev, D., Stajer, V., and Todorovic, N., 2022. Food creatine and head circumference among children aged 0\u20132 years. Current Developments in Nutrition, 6, p.699.<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/doi.org\/10.1080\/15502783.2025.2502094\" target=\"_blank\" rel=\"noopener noreferrer\">Smith-Ryan AE, DelBiondo GM, Brown AF, Kleiner SM, Tran NT, Ellery SJ. Creatine in women\u2019s health: bridging the gap from menstruation through pregnancy to menopause. J Int Soc Sports Nutr. 2025 Dec;22(1):2502094. doi: 10.1080\/15502783.2025.2502094. Epub 2025 May 15. PMID: 40371844; PMCID: PMC12086928.<\/a><\/em><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>This article examines the effects of creatine on women's health.<\/p>","protected":false},"author":1,"featured_media":10186,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[602092477,602092478],"tags":[602094342,602094341],"class_list":["post-10160","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-602092477","category-602092478","tag-602094342","tag-602094341"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 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